CHEST Guidelines-Clinimetric-Properties-of-the-Lung-Clearance-Index

Clinimetric-Properties-of-the-Lung-Clearance-Index

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The document comprises two correspondences that revolve around research published in the journal CHEST. The first correspondence is a response from Miguel Ángel Martínez-García, Francisco Campos-Rodriguez, and Ferrán Barbé, researchers from Spain, addressing Dr. Marvisi's interest in their article about the relationship between Obstructive Sleep Apnea (OSA) and cancer. The authors acknowledge various studies identifying pathophysiological pathways linking OSA to cancer, primarily through hypoxia and sleep fragmentation, and referenced immune system alterations in various cells. They emphasize their article's focus on clinical studies looking at the OSA-cancer relationship and suggest further reading for a deeper understanding. They express gratitude and encourage exploration of the extensive literature available on the subject.<br /><br />The second correspondence is a response to a commentary by Dr. Oude Engberink, Sanja Stanojevic, and Felix Ratjen on the clinimetric properties of Lung Clearance Index (LCI) in cystic fibrosis (CF) research. This team critiques a study conducted by O’Neill and colleagues, which evaluated LCI's variability and repeatability in CF patients. While appreciating the findings, the critics suggest that the study could explore more on the differences in metrics between healthy individuals and CF patients for better threshold establishment in medical intervention. In response, O’Neill and co-authors indicate their primary goal was comparing adults and children with CF rather than detailing healthy vs. disease variance. They address the feedback by providing additional analysis demonstrating variance and repeatability in healthy and CF groups, strengthening the existing study's conclusions.<br /><br />Both sections reveal a complex interplay between various health conditions and research methodologies, emphasizing the importance of in-depth analysis and cross-study engagement to enhance clinical understanding and intervention strategies.

Keywords

Obstructive Sleep Apnea

cancer

hypoxia

sleep fragmentation

immune system

Lung Clearance Index

cystic fibrosis

clinical studies

research methodologies

clinical intervention