CHEST Guidelines-Diversity-in-the-Pulmonary-Embolism-Response-Team-

Diversity-in-the-Pulmonary-Embolism-Response-Team-

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The document presents two main topics: research on lung clearance index (LCI) repeatability in cystic fibrosis (CF) patients and the development of pulmonary embolism response teams (PERT) in the United States.<br /><br />The LCI study discusses intra-visit variability among CF and healthy control (HC) subjects, observing higher variability in CF patients. It focuses on inter-visit repeatability data in CF patients, indicating stable LCI measurements across visits for both adults and children. No significant differences were found between the measurements, with mean percentage coefficient of variation (CV) slightly varying between the visits (4.3% on the first visit and 4.7% on the second). The study suggests that sample sizes should reflect CF patient data to avoid underpowering, noting similar variability across different ages and disease stages. These findings improve understanding of LCI's natural variability in CF and inform what constitutes a clinically meaningful change.<br /><br />The PERT study outlines the formation and diversity of PERT teams in the U.S., responsible for managing acute pulmonary embolism. Through a survey of National PERT Consortium members, it was discovered that most programs emerged in 2014/2015, involving specialties like pulmonary/critical care and interventional cardiology. These teams, generally comprising multiple specialties, did not correlate with the hospital's size or academic status and had varying activation frequencies. The study highlights the need for standardized definitions of pulmonary embolism severity and treatment protocols to improve quality of care and outcomes. The National PERT Consortium aims to establish a registry to gather relevant data to aid future clinical guidelines.<br /><br />Both reports emphasize targeted approaches and innovations in managing respiratory conditions, enhancing patient care through specialized research and structured team responses.

Keywords

lung clearance index

cystic fibrosis

repeatability

pulmonary embolism

response teams

inter-visit variability

clinical guidelines

National PERT Consortium

pulmonary care

patient outcomes