CHEST Guidelines-Introducing-High-Sensitivity-Cardiac-Troponin-T-as

Introducing-High-Sensitivity-Cardiac-Troponin-T-as

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The document comprises correspondence among researchers discussing the relationship between sleep disorders like Obstructive Sleep Apnea (OSA) and cardiovascular pathophysiology, with a focus on Obesity Hypoventilation Syndrome (OHS). The researchers debate the role of nocturnal hypoventilation and intermittent versus sustained hypoxemia (i.e., low oxygen levels) in the development of cardiovascular comorbidities in patients with OHS. Dr. Giorgio Castellana and colleagues from the University of Bari suggest that sustained hypoxemia might contribute to cardiovascular pathophysiology in such cases.<br /><br />In response, Dr. Juan F. Masa and colleagues concede that while intermittent hypoxemia appears to be linked with reduced cardiovascular morbidity in their data, the potential additive effects of sustained hypoxemia should not be ruled out entirely.<br /><br />Dr. Denis Monneret and other researchers advocate the use of biomarkers like high-sensitivity cardiac troponin T (hs-cTnT) to further investigate cardiovascular risks associated with OSA and OHS. They argue that these biomarkers could provide additional insights into the cardiovascular impact of OSA, given earlier studies linking higher hs-cTnT levels with increased cardiovascular risks.<br /><br />Dr. Masa and his team acknowledge these suggestions, emphasizing that their study's findings are preliminary and suggest a need for further inquiry into how OSA severity may afford protection against cardiovascular morbidity in OHS patients. Both parties agree that the integration of biomarkers such as hs-cTnT could enhance understanding of the relationship between OSA severity and cardiovascular health, emphasizing the complexity of these interrelations and the necessity for more comprehensive research to unravel them.<br /><br />Overall, the document underscores ongoing discussions and hypotheses within the medical community about the interplay between sleep apnea syndromes and cardiovascular disease, encouraging more nuanced research approaches including the use of sensitive biomarkers.

Keywords

Obstructive Sleep Apnea

Obesity Hypoventilation Syndrome

cardiovascular pathophysiology

nocturnal hypoventilation

intermittent hypoxemia

sustained hypoxemia

biomarkers

high-sensitivity cardiac troponin T

cardiovascular comorbidities

sleep disorders