CHEST Guidelines-Response_chest

Response_chest_5 (2)

Pdf Summary

The text consists of two letters to the editor concerning research articles published in medical journals focusing on sleep apnea and its cardiovascular and cancer implications.<br /><br />The first letter is a response from authors Juan F. Masa and colleagues to Dr. Chugh and others who showed interest in their article published in CHEST. The original study was a cross-sectional analysis centered on patients with obesity hypoventilation syndrome (OHS) from a clinical trial (NCT01405976), examining different treatment strategies. The authors emphasize that their study lacked the capacity to determine the incidence of cardiovascular events and was not a primary prevention trial for such events. They acknowledge potential selection bias due to patient enrollment criteria but argue their sample was representative. The authors call for further studies to explore their findings rigorously.<br /><br />The second letter from Maurizio Marvisi highlights a review on cancer and obstructive sleep apnea (OSA) by Martínez-García et al. Dr. Marvisi emphasizes the role of sleep fragmentation in weakening the immune system, which is crucial in cancer progression and other diseases. He notes how poor sleep quality affects the presence of immune cells like monocytes and natural killer cells, and mentions the association between sleep quality and telomere length in lymphocytes, suggesting further research is warranted in these areas.<br /><br />Both letters underscore the complex interactions between sleep disorders, cardiovascular health, and the immune system, advocating for continued investigation to better understand and manage these conditions.

Keywords

sleep apnea

cardiovascular implications

cancer implications

obesity hypoventilation syndrome

treatment strategies

immune system

sleep fragmentation

telomere length

natural killer cells

research studies