CHEST SEEK® Peer Review Discussions (1 New Video! August 2025)-Subtherapeutic Dosing of Voriconazole Resulting from a Drug-Drug Interaction

Subtherapeutic Dosing of Voriconazole Resulting from a Drug-Drug Interaction

Video Transcription

Video Summary

The video transcript discusses the importance of proper dosing of boriconazole to effectively treat invasive fungal disease. It also touches on the need for antibiotic susceptibility testing and the possibility of resistance developing quickly. Suggestions are made to include brain imaging for possible Aspergillus dissemination and to emphasize the range of Aspergillus infections beyond just the lungs. The discussion also explores the reasoning behind intubation in ICU patients and the consideration of hemoptysis as a symptom. Various clinical scenarios and educational points are highlighted throughout the conversation.

Asset Caption

Notable commentary from Drs. Hollenberg, Janz, Karam, Kruser, and Pickens.

Recorded in December 2023.

Meta Tag

Concept Invasive Fungal Infection

Concept Subtherapeutic Drug Level

Concept Invasive Aspergillosis

Concept Voriconazole

Concept Drug Interaction

Keywords

boriconazole dosing

invasive fungal disease treatment

antibiotic susceptibility testing

Aspergillus dissemination

hemoptysis symptom

Drug Interaction

Voriconazole

Invasive Aspergillosis

Subtherapeutic Drug Level

Invasive Fungal Infection