CHEST SEEK® Peer Review Discussions-Abnormality in Blood Smear Question

Video Transcription

Video Summary

In this video transcript, the participants discuss the number of lobes in neutrophil nuclei, with the correct average being 3.25 lobes instead of 3.5. They also mention the clinical significance of lamin deficiency in hereditary pelger-huet anomaly and whether it affects neutrophils or other lamin receptors. It is noted that most patients with pelger-huet anomaly do not have clinical problems, but there are rare cases where clinical issues arise. They discuss how viral illnesses, including COVID-19, can cause abnormal neutrophil nuclei, and the association between the magnitude of these cells and the severity of illness. The conversation also includes suggestions to tie these topics into clinical relevance and the need for a review paper on peripheral blood smears for intensivists. The concept of neutrophil nets is mentioned as possibly linked to the hyponucleation of neutrophils.

Asset Caption

Notable commentary from Drs. deBoisblanc, Hollenberg, Kruser, Provencio, and Schmidt.

Recorded in January 2022.

Keywords

neutrophil nuclei

lamin deficiency

pelger-huet anomaly

viral illnesses

peripheral blood smears